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Mesenchymal stem cells - MSC

Mesenchymal stem cell, source Robert M. Hunt for Wikipedia.

In addition to blood-forming hematopoietic stem cells, human bone marrow also contains mesenchymal stem cells (MSC). Nearly 140 years ago the German pathologist Conheim discovered that bone marrow derived cells had to be part of the wound healing process. Stem cells that are able to differentiate into mesenchymal cell types have been first identified and described by Friedenstein, Owen and Caplan. The classical stem cell thesis of the hemotopoiesis (blood-forming ability) has later been transferred to connective tissue cells and their ability to form bone, cartilage, fat and stromal cells from a mesenchymal cell. These scientists have furthermore adopted the thesis that mesenchymal stem cells are furthermore capable to rejuvenate/reproduce themselves, expand and differentiate into various cell types such as osteoblasts (bone-building cells), chondroblasts (cartilage-building cells), myoblasts (muscle-building cells) and tentocytes (tendon-building cells).

Non-hematopoietic bone marrow cells that not only are capable to renew themselves, but also have the characteristics of multipotent differentiation are called mesenchymal stem cells (MSC).

Further investigations regarding the differentiation capacity of these cells brought indications that MSC – after a corresponding induction – can adopt into cell types with endodermal or ectodermal characteristics. The so inducted cells possessed the characteristics of hepatocytes (liver cells), paematopoetic cells, pancreas cells or neuronal cells (nerve cells). Newer results demonstrate a much complex biology of MSC than previously assumed. These cells dispose of immune-modulators or suppressive capacities, they can inhibit the proliferation of T-, B- and NK-Cells as well as the differentiation of dendric cells. MSC are considered to be hypo-immunogenic, they are able to synthesize a number of cytokines and growth factors, steer immuneregulationg processes and support haematopoiesis. The presence of multiple chemokine receptors on the MSC cells suggests that these cells are able to immigrate into other organs in order to regenerate them.

 MSC cells are very suitable for the repair and regeneration of tissue due to their multi-differentiation capacity, their excellent expansion capacity and their ability to produce trophic factors extracellular matrix proteins as well as their immunemodulatory capacities. 

 

 

 

 

 

Therapy Spectrum 

 

ACS - Autologous Conditioned Serum

 

ACP - Autologous Conditioned Plasma

 

ACBM - Autologous Concentrated Bone Marrow

 

Hyaluronic Acid

 

Alternative Therapies 

 

Homeopathy 

 

DNA Analysis